The effect of exercise on skeletal muscle glucose uptake in type 2 diabetes: An epigenetic perspective
Santos JM, Moreli ML, Tewari S, Benite-Ribeiro SA. 2015. The effect of exercise on skeletal muscle glucose uptake in type 2 diabetes: An epigenetic perspective. Metabolism. 64(12):1619–1628.
Question 1: Look at figure 2. What are the three major epigenetic mechanisms that regulate gene expression, and at which stage of transcription-translation do they act?
The first paragraph of section 3 reviews insulin cellular pathways, which we also discussed in detail earlier this semester. Answer the following 3 review questions about how this pathway works:
Question 2: What type of hormone receptor is the insulin receptor? How many insulin molecules must bind to it to activate the receptor?
Question 3: What do GLUT4 vesicles do?
Question 4: This section focuses on the short-term effects of insulin, but what was the long-term pathway we discussed previously?
Question 5: According to this review, what effect does exercise have on GLUT4 activity in skeletal muscle, and what is one proposed mechanism?
Question 6: Based on this reading and other material you have seen, how is exercise related to type 2 diabetes?